Cajun Chicken & Sweet Potato Casserole

By Krista Pool

5 from 1 vote

on Feb 12, 2026

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This Cajun Chicken & Sweet Potato Casserole is one of those high-protein, comfort-food meals that checks all the boxes: cozy, flavorful, and macro-friendly. The sweet potatoes bring natural sweetness and fiber, while the creamy Cajun-spiced chicken makes it feel indulgent without blowing your numbers. It’s hearty enough for dinner and perfect for meal prep lunches all week.

Cajun Chicken & Sweet Potato Casserole showing completed recipe in a casserole dish with visible sweet potatoes, spinach, chicken, sauce, and topped with melted cheese.

Table of Contents

Macros per Serving

Makes: 6.5 servings

Serving Size: 300g

Calories: 391

Macros: 37p / 30.6c / 12.8f (4.8 fiber)

How to Log It

Search “Stay Fit Mom Cajun Chicken & Sweet Potato Casserole” in MyFitnessPal or MacrosFirst for easy tracking.

Small bowls with labeled ingredients including: sweet potatoes, cream cheese, spices, olive oil, shredded mozzarella cheese, tomato paste, parmesan cheese, chicken breast, spinach garlic, and red onion.

Ingredients

For the Sweet Potatoes:

  • Sweet potatoes
  • Paprika
  • Salt
  • Black pepper
  • Avocado or olive oil spray

For the Chicken:

  • Boneless, skinless chicken breast
  • Smoked paprika
  • Garlic powder
  • Onion powder
  • Oregano
  • Thyme
  • Black pepper
  • Salt

Remaining Ingredients:

  • Avocado or olive oil
  • Garlic, minced
  • Red onio
  • Water
  • Tomato paste
  • ⅓-less-fat cream cheese
  • Fresh spinach
  • Shredded mozzarella cheese (freshly shredded melts best)
  • Parmigiano Reggiano
9x13 pan with diced sweet potatoes.

Substitutions & Swaps

  • Chicken thighs: Can be used instead of chicken breast for a richer flavor (macros will change).
  • Dairy-free: Swap the cream cheese for a dairy-free alternative and omit or replace the cheese topping.
  • Spinach: Kale or Swiss chard work well if that’s what you have on hand.
  • Tomato paste: You can substitute crushed tomatoes, but the sauce will be slightly thinner.

Recipe Tip

Cutting the sweet potatoes into even ½-inch cubes is key for consistent roasting and the best texture in the final dish.

Variations

  • Extra heat: Add cayenne pepper or red pepper flakes to the chicken seasoning.
  • Veggie-packed: Add bell peppers, zucchini, or mushrooms to the skillet with the onion.
  • Higher calorie option: Serve over rice or add an extra layer of cheese on top.
Sauce pan with chicken, spinach, and sauce.

Macro-Friendly & Meal Prep Approved

With 37 grams of protein per serving, this casserole is filling and balanced. It reheats beautifully and holds up well in the fridge, making it a great option for busy weeks when you want something warm and satisfying ready to go.

Storage & Reheating

  • Refrigerator: Store in airtight containers for up to 4–5 days.
  • Reheat: Microwave individual portions or warm in the oven until heated through.
  • Freezer: Can be frozen, though the cream sauce may slightly change texture when thawed.
Side by side image of casserole. On the left the completed casserole ready to bake and the one on the left baked and a serving removed with a wooden spoon in the dish.

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Supplies Used

9×13 Casserole Dish – This size pan is a staple in any kitchen! It’s perfect for family-sized casseroles!

10.5″ Fry Pan – This pan is nonstick and great for so many recipes!

More SFM Casseroles to Try

  1. Spaghetti Casserole
  2. Cowboy Cornbread Casserole
  3. Mexican Street Corn Casserole

Get the Stay Fit Mom Cookbooks!

Macros included for all recipes and pre loaded in the apps for easy macro tracking!

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5 from 1 vote

Cajun Chicken & Sweet Potato Casserole

By: Krista Pool
Cajun Chicken & Sweet Potato Casserole is a high-protein, macro-friendly dinner made with tender Cajun-seasoned chicken breast, roasted sweet potatoes, and a creamy tomato-based sauce with spinach and melted cheese. This easy, one-pan casserole is perfect for meal prep, family dinners, and healthy comfort food cravings, with 37 grams of protein per serving and bold Cajun flavor in every bite.
Prep: 20 minutes
Cook: 1 hour
Servings: 6.5 servings
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Equipment

Ingredients 

For the Sweet Potatoes

  • 3 medium sweet potatoes, peeled and diced (900g)
  • 1/4 teaspoon paprika
  • 1/2 teaspoon salt
  • 1/8 teaspoon black pepper
  • Avocado or olive oil spray, about 14g total

For the Chicken

  • 2 pounds boneless, skinless chicken breast, cubed
  • 2 teaspoons smoked paprika
  • 1 teaspoon garlic powder
  • 1 teaspoon onion powder
  • 1 teaspoon oregano
  • 1 teaspoon thyme
  • 1/4 teaspoon black pepper
  • 1/2 teaspoon salt

Remaining Ingredients

  • 1/2 tablespoon avocado or olive oil
  • 1 clove garlic, minced
  • 1/4 cup diced red onion, 30g
  • 3/4 cup water
  • 4 tablespoons tomato paste
  • 8 tablespoons ⅓-less-fat cream cheese
  • 5 ounces fresh spinach
  • 1/2 cup shredded mozzarella cheese, 56g, freshly shredded melts best
  • 1/4 cup shredded Parmigiano Reggiano, 28g

Instructions 

  • Preheat the oven to 400°F.
  • Place the diced sweet potatoes in a 9×13 casserole dish. Spray with cooking oil and season with paprika, salt, and pepper. Toss to evenly coat.
  • Bake for 55 minutes, stirring once halfway through for even cooking.
  • While the potatoes bake, place the cubed chicken in a bowl. Add all chicken seasonings and toss until evenly coated.
  • When the potatoes have about 20 minutes left, heat the oil in a large skillet over medium-high heat.
  • Add the garlic and red onion and cook for about 30 seconds, until fragrant.
  • Add the chicken and cook, stirring occasionally, until browned on all sides and cooked through.
  • Reduce heat to medium-low. Add the water and tomato paste and stir well.
  • Add the cream cheese and stir until fully melted and the sauce is smooth.
  • Add the spinach and gently stir until wilted, about 2–3 minutes.
  • Remove the sweet potatoes from the oven and give them a quick toss.
  • Spoon the creamy Cajun chicken mixture evenly over the potatoes. Top with mozzarella and Parmesan.
  • Return to the oven and bake for 5 minutes, or until the cheese is melted.

Notes

  • Find in Myfitnesspal or Macrosfirst food database by searching for, “Stay Fit Mom Cajun Chicken Sweet Potato Casserole.”

Nutrition

Serving: 300g, Calories: 391kcal, Carbohydrates: 30.6g, Protein: 37g, Fat: 12.8g, Fiber: 4.8g
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